|
rs7254880
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In analyses of genetically independent cases and controls, four of the seven single markers show strong evidence for association with AD (0.00003<Fisher's exact P<0.001), and the most significant single marker, rs7254880, tags an associated haplotype with frequency 0.071 in cases compared to 0.034 in controls (chi2 15.563, P<0.00008, 5000 permutation P<0.001, OR 2.17); inclusion of affected siblings gives similar results.
|
16940975 |
2006 |
|
rs1701137
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD.
|
19204064 |
2010 |
|
rs57083693
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families.
|
24962325 |
2014 |
|
rs3736802
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53.
|
23089632 |
2013 |
|
rs1799913
|
|
|
0.010 |
GeneticVariation |
BEFREE |
When patients with comorbid alcohol use disorder (AUD) were removed, given that TPH1 has been associated with alcoholism, the associations of those recovered from SI with TPH1 rs1799913 remained significant for the additive (increased recovery with AC, P = 0.045) and recessive (increased recovery with C-carriers, P = 0.008) models, and with 5-HTTLPR using the dominant model (increased recovery with S'S', P = 0.016).
|
30923939 |
2019 |
|
rs1800532
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Our aim was to assess the association of TPH1 A218C polymorphism (rs1800532) with mood disorders, including major depressive disorder and bipolar disorder, and alcohol dependence by using meta-analysis.
|
21601290 |
2012 |
|
rs11623335
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.
|
21956439 |
2012 |
|
rs10514299
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Association analyses in the NIAAA sample showed a trend-level relationship between rs10514299 and a lifetime AD diagnosis in the European American subgroup (odds ratio = 0.82, p = 0.09).
|
30006604 |
2018 |
|
rs1869324
|
|
|
0.700 |
GeneticVariation |
GWASDB |
A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.
|
21703634 |
2011 |
|
rs10496768
|
|
|
0.010 |
GeneticVariation |
BEFREE |
The top hit of PKNOX2 (rs750338 with p=1.47 × 10(-6)) in the meta-analysis was replicated with the Australian Twin-Family Study of 778 families (p=1.39 × 10(-2)) Furthermore, several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample (top SNPs were rs2269655, rs856613, and rs10496768 with p=4.58 × 10(-3), 2.1 × 10(-4), and 2.86 × 10(-3) for KIAA0040, NRD1 and THSD7B, respectively).
|
21703634 |
2011 |
|
rs6356
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Tyrosine hydroxylase Val-81-Met polymorphism associated with early-onset alcoholism.
|
15722952 |
2005 |
|
rs3771856
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Four single-nucleotide polymorphisms (rs3771829, rs3771833, rs3771856, and rs1701137) at the TACR1 gene, previously known to be associated with bipolar disorder or alcoholism, were strongly associated with ADHD.
|
19204064 |
2010 |
|
rs6715729
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analyses indicated two risk haplotypes for AD in the 5' end of the gene, formed by the three-SNP combinations rs6715729-rs735668-rs6741029.
|
19553914 |
2009 |
|
rs3771829
|
|
|
0.010 |
GeneticVariation |
BEFREE |
To further elucidate the role of TACR1 in affective disorders, rs3771829 was genotyped in a second BPAD sample of 593 subjects (UCL2), in 997 subjects with ADS, and a subsample of 143 individuals diagnosed with BPAD and comorbid alcohol dependence (BPALC). rs3771829 was associated with BPAD (UCL1 and UCL2 combined: P = 2.0 × 10(-3)), ADS (P = 2.0 × 10(-3)) and BPALC (P = 6.0 × 10(-4)) compared with controls screened for the absence of mental illness and alcohol dependence.
|
24817687 |
2014 |
|
rs735668
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Haplotype analyses indicated two risk haplotypes for AD in the 5' end of the gene, formed by the three-SNP combinations rs6715729-rs735668-rs6741029.
|
19553914 |
2009 |
|
rs1000579
|
|
|
0.800 |
GeneticVariation |
GWASCAT |
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
|
22004471 |
2012 |
|
rs1000579
|
|
|
0.800 |
GeneticVariation |
GWASDB |
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.
|
22004471 |
2012 |
|
rs1000579
|
|
G |
0.800 |
GeneticVariation |
GWASCAT |
Genetic Contribution to Alcohol Dependence: Investigation of a Heterogeneous German Sample of Individuals with Alcohol Dependence, Chronic Alcoholic Pancreatitis, and Alcohol-Related Cirrhosis.
|
28714907 |
2017 |
|
rs11583322
|
|
|
0.700 |
GeneticVariation |
GWASDB |
Dosage transmission disequilibrium test (dTDT) for linkage and association detection.
|
23691058 |
2013 |
|
rs79246196
|
|
C |
0.700 |
GeneticVariation |
GWASCAT |
Genetic Risk Variants Associated With Comorbid Alcohol Dependence and Major Depression.
|
29071344 |
2017 |
|
rs2567608
|
|
|
0.010 |
GeneticVariation |
BEFREE |
Additionally, we suggest that patients with AD of the <i>SSTR4</i> rs2567608 TT genotype may be more vulnerable to ACEs and at a higher risk of suicide attempt.
|
28924491 |
2017 |
|
rs523349
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we explored whether functionally relevant genetic polymorphisms in SRD5A2 (V89L, A49T, [TA](n)) are linked to alcohol addiction and craving.
|
22707254 |
2012 |
|
rs9282858
|
|
|
0.010 |
GeneticVariation |
BEFREE |
In this study, we explored whether functionally relevant genetic polymorphisms in SRD5A2 (V89L, A49T, [TA](n)) are linked to alcohol addiction and craving.
|
22707254 |
2012 |
|
rs248793
|
|
|
0.020 |
GeneticVariation |
BEFREE |
We previously reported that a common nonsynonymous polymorphism, AKR1C3 2 in the gene encoding the enzyme 3α-HSD2/17β-HSD5, and a synonymous single nucleotide polymorphism (SNP), rs248793, in SRD5A1, which encodes 5α-reductase, were associated with alcohol dependence (AD).
|
24838369 |
2014 |
|
rs248793
|
|
|
0.020 |
GeneticVariation |
BEFREE |
The minor allele for both SNPs was more common among controls than subjects with AD: SRD5A1 rs248793 C-allele (χ(2)(1) = 7.6, p = 0.006) and AKR1C3 rs12529 G-allele (χ(2)(1) = 14.6, p = 0.0001).
|
21323680 |
2011 |